Journal: Redox Biology
Article Title: Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress
doi: 10.1016/j.redox.2022.102594
Figure Lengend Snippet: Silencing α7nAChR blocked the high AF susceptibility and atrial electrical anomalies of APP/PS1 mice. (A) Representative electrocardiogram AF episodes induced by intra-atrial burst pacing. (B) Quantitative analysis of AF incidence (n = 10). (C) Quantitative analysis of AF duration (n = 10). (D) Schematic of the experimental design of epicardial electrical mapping recording. (E) Successive isochronal conduction maps of left atria of WT and APP/PS1 mice. Black arrow means ectopic pacing. (F) Quantitative analysis of atrial conduction velocity (n = 6). (G) Quantitative analysis of Inhomogeneity index (n = 6). Data were presented as Mean ± S.D. ns P > 0.05, * P < 0.05, ** P < 0.01 and *** P < 0.001.
Article Snippet: A surface 3-lead echocardiogram (ECG) was recorded (FE132-0641, ADinstruments Co Ltd., New South Wales, Australia) and analyzed with LabChart 8 (ADinstruments Co Ltd., New South Wales, Australia).
Techniques: